3D-bioprinted bio-actuator based on skeletal muscle used as a force measurement platform. Using this setup, we have performed studies on the adaptability of bio-actuators after applying different training protocols and we have observed how their force generation and gene expression can adapt to the frequency of stimulation and stiffness of the artificial posts. By controlling the contractions of skeletal muscle cells via electric fields, we can measure the forces exerted by these bio-actuators against artificial 3D-printed posts. Theses materials can act as scaffolds, support, or flexible parts, as well as be responsive upon certain stimuli. In particular, we take advantage of the 3D bioprinting technique to develop bio-robotic systems composed of skeletal muscle cells embedded in biocompatible hydrogels, which can be 3D bioprinted alongside other artificial materials. In the research line of soft bio-hybrid robotics, we explore the integration of biological tissue and artificial materials at larger length scales. Journal of the American Chemical Society (2018), 140, 7896-7903Įnzyme‐Powered Nanobots Enhance Anticancer Drug DeliveryĪC Hortelão, T Patiño, A Perez‐Jiménez, À Blanco, S SánchezĪdvanced Functional Materials (2018), 28, 1705086 Tania Patiño, Natalia Feiner-Gracia, Xavier Arqué, Albert Miguel-López, Anita Jannasch, Tom Stumpp, Erik Schäffer, Lorenzo Albertazzi, Samuel Sánchez Influence of enzyme quantity and distribution on the self-propulsion of non-Janus urease-powered micromotors Tania Patiño, Xavier Arqué, Rafael Mestre, Lucas Palacios, Samuel SánchezĪccounts of chemical research (2018) 51, 2662-2671 Hortelão, Rafael Carrascosa, Nerea Murillo-Cremaes, Tania Patiño, Samuel Sánchezįundamental Aspects of Enzyme-Powered Micro-and Nanoswimmers Targeting 3D Bladder Cancer Spheroids with Urease-Powered NanomotorsĪna C. Tania Patiño, Alessandro Porchetta, Anita Jannasch, Anna Lladó, Tom Stumpp, Erik Schäffer, Francesco Ricci, Samuel Sánchez Self-sensing enzyme-powered micromotors equipped with pH responsive DNA nanoswitches Xavier Arqué, Adrian Romero-Rivera, Ferran Feixas, Tania Patiño, Sílvia Osuna, Samuel Sánchez Intrinsic enzymatic properties modulate the self-propulsion of micromotors Xavier Arqué, Xavier Andrés, Rafael Mestre, Bernard Ciraulo, Jaime Ortega Arroyo, Romain Quidant, Tania Patiño, Samuel Sánchez Ionic Species Affect the Self-Propulsion of Urease-Powered Micromotors Smart micro- and nanorobots are able to swim, monitor their own activity, sense their environment and deliver drugs to 3D bladder cancer spheroids using biocompatible and bioavailable fuels such as urea. We have recently demonstrated that using enzyme-powered nanomotors can enhance anti-cancer drug delivery in vitro, improve the targeting of 3D bladder cancer spheroids and sense their surrounding environment. We are also interested in understanding the fundamental aspects underlying the motion of biocatalytic microswimmers for a safe and efficient design of micro- and nanomotors. Our group has demonstrated the use of different enzymes, including urease and glucose oxidase, to generate active propulsion of nano- and microparticles, paving the way towards new applications of artificial active matter in biomedicine. The use of enzyme catalysis is emerging as an attractive alternative to power micro- and nanomachines due to their unique features including biocompatibility, versatility and fuel bioavailability. We are interested in fundamental studies of active matter, the use of nanobots for future nanomedicine and environmental applications and the bioengineering of new devices based on hybrid systems. We develop different Systems ranging from active nanoparticles (nanobots), 3D Bioprinted Actuators and flexible biosensors.
IBEC is committed to turning research results into practical applications, providing innovative solutions to industry and to hospitals, and, ultimately, to society. Signal and Information Processing for Sensing Systems.Protein Phase Transitions in Health and Disease.Nanoscale bioelectrical characterization.Molecular Imaging for Precision Medicine.Molecular and Cellular Neurobiotechnology.Biomimetic systems for cell engineering.Biomedical signal processing and interpretation.Bioinspired Interactive Materials and Protocellular Systems.Biomaterials for Regenerative Therapies.Bacterial infections: antimicrobial therapies.
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